VHK is a systemic disease associated with abnormal reduction of melanin. It also affects the eye and causes the reduction of visual function. Miura used our custom-developed polarization sensitive optical coherence tomography (PS-OCT) to evaluate the melanin in the choroid, which is the layer beneath the retina. His study revealed that the PS-OCT imaging can be used to evaluate the stages of VKH.
The details of his research is published in Scientific Reports.
Citation: M. Miura, S. Makita, Y. Yasuno, S. Azuma, T. Mino, T. Yamaguchi, T. Iwasaki, R. Nemoto, H. Shimizu, and H. Goto, "Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography," Sci. Rep. 12, 3526 (2022), https://doi.org/10.1038/s41598-022-07591-9
>> Full-length article (open access).
原田病はメラニンの異常な減少を伴う全身性の疾患です。原田病は眼にも影響を及ぼし、視機能の低下を引き起こします。三浦は、私たちの開発した眼底イメージング用の偏光感受型光コヒーレンストモグラフィー装置(PS-OCT)を用いて、網膜さらに奥にある組織「脈絡膜」のメラニンを評価しました。その結果、VKHの病期PS-OCTで評価することができることが明らかになりました。
この研究の詳細は、Scientific Reports に論文として掲載されています。
Citation: M. Miura, S. Makita, Y. Yasuno, S. Azuma, T. Mino, T. Yamaguchi, T. Iwasaki, R. Nemoto, H. Shimizu, and H. Goto, "Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography," Sci. Rep. 12, 3526 (2022), https://doi.org/10.1038/s41598-022-07591-9
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