Monday, January 1, 2024

Publication: The accuracy of polarization measurement can be improved by multiple-scattering rejection

Our colleague, Lida Zhu, recently reported a new method to enable volumetric three-dimensional (3D) polarization property measurement with improved accuracy.

Polarization-sensitive optical coherence tomography (PS-OCT) is an optical tomographic modality enabling 3D imaging of polarization properties (i.e., birefringence and polarization uniformity) of biological tissue. Although PS-OCT has been successful, it was recently found that the accuracy of polarization imaging is significantly degraded in the deep regions of the tissue due to noise originating from multiple-scattering photons (MS-photons).

Lida introduced his own developed MS-photon rejection method, which is the active probe-beam-focus modulation followed by holographic signal processing, into PS-OCT. His careful study using scattering phantom and postmortem small samples proved the improved accuracy of PS-OCT by this method.

The details of this research are published in Biomedical Optics Express.

Citation: L. Zhu, S. Makita, J. Tamaoki, Y. Zhu, P. Mukherjee, Y. Lim, M. Kobayashi, and Y. Yasuno, “Polarization-artifact reduction and accuracy improvement of Jones-matrix polarization-sensitive optical coherence tomography by multi-focus-averaging based multiple scattering reduction," Biomed. Opt. Express 15, 256-276 (2024). https://doi.org/10.1364/BOE.509763

>> Full article (open access)

私たちの研究室の Lida Zhu さんが3次元生体偏光計測の精度を向上するための新しい方法を開発しました。

偏光感受型光コヒーレンストモグラフィー(PS-OCT)は、生体組織の偏光特性(複屈折と偏光均一性)の3次元イメージングを可能にする光断層技術です。これまで PS-OCT は様々な生体計測に適用されてきましたが、多重散乱光に由来するノイズのために、組織の深部では計測精度が著しく低下することがわかってきました。

Lida Zhu さんは、独自に開発した多重散乱光除去法をPS-OCTに導入しました。この方法は、OCTのプローブ光の焦点の変調とホログラフィック信号処理を組み合わせたものです。散乱ファントム(疑似試料)と固定小型魚サンプルを用いた研究により、この手法によるPS-OCTの精度向上が証明されました。

この研究の詳細は米光学会の研究誌 Biomedical Optics Express に掲載されました。

Citation: L. Zhu, S. Makita, J. Tamaoki, Y. Zhu, P. Mukherjee, Y. Lim, M. Kobayashi, and Y. Yasuno, “Polarization-artifact reduction and accuracy improvement of Jones-matrix polarization-sensitive optical coherence tomography by multi-focus-averaging based multiple scattering reduction," Biomed. Opt. Express 15, 256-276 (2024). https://doi.org/10.1364/BOE.509763

>> Full article (open access)

(この記事の日本語版は www.DeepL.com で翻訳したものを一部修正したものです。)